East Indian Sandalwood oil from Santalum album is defined by exceptionally high concentrations of (Z)-a-santalol (45-55%) and (Z)-β-santalol (20-25%) — the sesquiterpenoid alcohols responsible for its benchmark creamy, sweet, and long-lasting woody character.^[1] A human transdermal absorption study found that a-santalol alone produced measurable physiological changes consistent with a relaxing and sedative effect, while the whole oil simultaneously provoked behavioural activation — a nuanced pharmacodynamic profile supporting its use in both calming and alerting aromatherapy contexts.^[2] Clinical trials have further demonstrated that Santalum album oil is safe and well-tolerated in topical applications for acne, atopic dermatitis, psoriasis, and Molluscum contagiosum, with anti-inflammatory effects mediated partly through COX-1, COX-2, and 12-lipoxygenase inhibition.^[3]